Numerical Investigation of Double Emulsion Droplets using Modified Flow Focusing Microfluidic Device for Drug Delivery

Double emulsion droplets generation is convenient for drug delivery applications since the core-shell template has ability to increase success of target and release drug. In this study, modified flow-focusing microfluidics device proposed generate double with high monodispersity throughput, satisfying industrial needs. The W/O/W (water-in-oil-in-water) encapsulation a common combination in delivery. research aims analyze using 2D Volume Fluid (VoF) VoF approach, which able visualize flow regime, average diameter, Coefficient Variation (CoV), rate. Combination water-in-olive oil-in-water was used as working fluids. diameter droplets, CoV, rate obtained image processing. simulation results showed that injection model sudden expansion successfully produced two dripping instabilities. narrowing jetting regime obtained, including its evolution. both outer inner were achieved their droplet's generated can potentially be implemented delivery, although must further investigated. Nevertheless, control high-throughput droplets.